Table 2. The most represented mature miRNAs in mice cortices.

The mature miRNAs were annotated with Gene Ontology in relation to a biological process using the QuickGO database [27].

MIRNA NAME	GO ID	GO DESCRIPTION
MMU-MIR-22-3P	GO:0035195	gene silencing by miRNA
	GO:0051152	positive regulation of smooth muscle cell differentiation
	GO:2001200	positive regulation of dendritic cell differentiation
MMU-MIR-26A-5P	GO:0010459	negative regulation of heart rate
	GO:0032286	central nervous system myelin maintenance
	GO:0035195	gene silencing by miRNA
	GO:0045379	negative regulation of the interleukin-17 biosynthetic process
	GO:0045409	negative regulation of the interleukin-6 biosynthetic process
	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
	GO:0090370	negative regulation of cholesterol efflux
	GO:0150079	negative regulation of the neuroinflammatory response
	GO:1903609	negative regulation of inward rectifier potassium channel activity
MMU-MIR-128-3P	GO:0010985	negative regulation of lipoprotein particle clearance
	GO:0035195	gene silencing by miRNA
	GO:0042632	cholesterol homeostasis
	GO:0055088	lipid homeostasis
	GO:0090370	negative regulation of cholesterol efflux
	GO:0150078	positive regulation of the neuroinflammatory response
	GO:1903980	positive regulation of microglial cell activation
MMU-MIR-181A-5P	GO:0032691	negative regulation of interleukin-1 beta production
	GO:0032715	negative regulation of interleukin-6 production
	GO:0032720	negative regulation of tumor necrosis factor production
	GO:0035195	gene silencing by miRNA
	GO:0050723	negative regulation of the interleukin-1 alpha biosynthetic process
	GO:0050728	negative regulation of the inflammatory response
MMU-MIR-125A-5P	GO:0010629	negative regulation of gene expression
	GO:0035278	miRNA mediated inhibition of translation
	GO:1903671	negative regulation of sprouting angiogenesis