Table 1:
Combined study demographics, including % with history of psychotic disorder, frequency of deletion subtypes (3Mb A-D and 1.5Mb A-B are most common), and common psychotropic medications (at the time of scan). Other deletions include nested A-C, B-D, C-E, D-F, and D-G breakpoints. Groups did not differ in terms of age or sex distribution, but IQ was significantly lower in 22q11DS subjects vs. HC (p = 1.7 x 10−136).
| Healthy Control (HC) | (sd) / (%) | 22q11DS | (sd) / (%) | |
|---|---|---|---|---|
| N | 330 | 533 | ||
| Age (mean (sd)) | 18.14 | −9.24 | 17.85 | −8.6 |
| IQ (mean (sd)) | 110.64 | −15.35 | 74.95 | −12.53 |
| Sex = Female (%) | 148 | −44.88 | 275 | −51.6 |
| Psychotic_Disorder (%) | 0 | 0 | 73 | −13.8 |
| Deletion_Type (%) | ||||
| A-B | 0 | 0 | 28 | −8 |
| A-D | 0 | 0 | 311 | −88.6 |
| Other | 0 | 0 | 12 | −3.5 |
| Current Medication (%) | ||||
| Typical Antipsychotic | 0 | 0 | 15 | −3 |
| Atypical Antipsychotic | 0 | 0 | 72 | −14.5 |
| Lithium | 0 | 0 | 4 | −0.8 |
| Anticonvulsant | 1 | −0.4 | 31 | −6.3 |
| Antidepressant | 5 | −1.8 | 95 | −19.2 |
| Psychostimulant | 5 | −1.8 | 65 | −13.1 |