FIGURE 3.

Sharing of somatic mutation profiles defined by multiregional sequencing. A, Sharing pattern of somatic single nucleotide variants (SNV) among five tissues. Somatic SNV fulfilling the following criteria were used: (a) SNV whose mutant allele frequency (MAF) were greater than or equal to 0.15 in at least one epithelium or stromal sample; (b) SNV located on coding exons; and (c) SNV whose MAF in blood did not exceed 0.15. B, Distribution of MAF of the SNV shared by epithelium samples. The statistical significance of the differences was assessed using the Wilcoxon‐Mann‐Whitney test