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. 2020 Jun 20;111(8):2665–2671. doi: 10.1111/cas.14496

Figure 1.

Figure 1

Ferroptosis as an imbalance between catalytic Fe(II) and sulfhydryls (S). Ferroptosis is defined as catalytic Fe(II)‐dependent regulated necrosis with lipid peroxidation. Blue filled circle, Fe(III); red filled circle, Fe(II); DMT1, divalent metal transporter 1; GPX4, glutathione peroxidase 4; xCT, cystine‐glutamate antiporter. Refer to the text for details