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. 2020 Aug 7;477(15):2791–2805. doi: 10.1042/BCJ20200477

Figure 6. Structural profiles of UGT variants based on substrate specificity.

Figure 6.

The 2D t-SNE plots illustrate the latent spaces of the enzymes exhibiting positive activity for (A) UDP-Glc, (B) UDP-Gal, and (C) UDP-GlcNAc. The 2D t-SNE plots illustrate the latent spaces of the wildtype UGT 76E4 and the mutant 76E4 K275L against (D) UDP-Glc, (E) UDP-Gal, and (F) UDP-GlcNAc.