Fig. 1.

Distribution of LCR16a duplications in primate genomes. The location of LCR16a duplication blocks in marmoset (green dash), macaque (black dash), orangutan (blue dash), and human (red dash) are mapped against the GRCh38 human ideogram. The single-copy macaque locus maps to chr16p13, the ancestral origin from which all other copies were derived. Human LCR16a has expanded intrachromosomally across chromosome 16 predominantly on the short arm of chr16p. A more ancient copy of LCR16a, which is no longer expressed, locates to human chromosome 18. Marmoset and orangutan show expansions on other chromosomes including chr11 and chr13, respectively. Single-copy LCR16a duplication blocks are also mapped to chromosomes 20, 4, and 17/13 in the marmoset lineage