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. 2020 Aug 10;21:202. doi: 10.1186/s13059-020-02074-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Comparison of mouse BAC transgenic and NPIP expression. a RT-PCR of cDNA obtained from a panel of mouse transgenic tissues. Mouse lines (I13.49) derived from baboon (RPCI41-285I13) BAC integration demonstrate robust expression in the testis. This is a single copy of NPIP and orthologous to the ancestral location. b RT-PCR of cDNA generated from a panel of mouse transgenic tissues carrying human BAC clones with different NPIP paralogs. Mouse transgenic A15.3.8 (RP11-1381A15 NPIPA7), H15.1 (RP11-344H15 PKD1P6-NPIPP1), and O14.1 (RP11-1236O14 NPIPA1) each show a ubiquitous pattern of tissue expression. The H15.1 line shows two distinct bands because this locus contains a tandem duplication of exon 2 resulting two sets of products by RT-PCR. c Organization and sequence composition of large-insert BAC clones used in mouse transgenic experiments. Annotations include SDs (colored arrows), gene models with the direction of transcription, and DupMasker annotation [20]. The baboon and three distinct human NPIP loci exhibit a diverse set of flanking duplicons and LCR16a copies