Figure 2.

Overexpression of miR-194-5p Decreases Bone Mass and Promotes Osteoporosis in Aged Mice

(A) Representative images of the femur of aged male mice. (B–E) Quantification of trabecular BV/TV (B), Tb.Sp. (C), Tb.N. (D), and Tb.Th. (E) of mice from the two groups. (F and G) Quantification of trabecular Ct.Th. (F) and BMD (G) of mice from the two groups. (H) H&E staining of the femoral metaphysis and quantification of the bone area. (I) TRAP staining of the femoral metaphysis and quantification of the TRAP-positive area. (J) Representative images of BMP2-positive osteoblasts on the surface of trabecular bone. n = 6. ∗∗∗p < 0.01, ∗∗∗∗p < 0.0001.