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. 2020 Aug 11;11:4017. doi: 10.1038/s41467-020-17847-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Mucins from different samples were pre-treated with the broad acting sialidase BT0455^GH33 and then digested with the GH16 and products analysed by LC-FLD-ESI-MS. a Inflamed colonic tissue removed during a laproascopic panproctocolectomy from a patient with UC. b Bowel tissue from neonates with necrotising enterocolitis. c Colorectal cancer cell lines. Small amounts of Neu5Gc are seen in some of the UC samples (e.g., panel a) suggesting either the presence of contaminating dietary animal O-glycans remaining in the mucus layer or that this xenobiotic sugar has been incorporated into human mucins from dietary sources. The O-glycan profiles of all the different samples analysed are shown in Supplementary Fig. 21.