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a Hydrophobic regions of PrP highlighted in yellow. b Comparison of the electrostatic surface between the wild-type PrP and variants. The human PrP protein consists of 253 amino acids. PrPC contains an octapeptide repeat-containing unfolded domain at the N-terminal tail, three α-helices (α1, α2, and α3), antiparallel β-sheets (β1 and β2), and a GPI-anchor signal at the C-terminal tail
