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. 2020 Jul 8;20(3):257–266. doi: 10.1007/s40268-020-00315-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Distribution of residuals. a Representation of the normal distribution of residuals. The dashed line represents the theoretical distribution defined in the developed model and the bars the distribution of the observed data. b Homogeneous distribution of weighted residuals in relation to time. c Homogeneous distribution of weighted residuals in relation to predicted plasma concentration. IWRES weighted individual residual, NPDE normalized predicted errors, PWRES weighted population residual