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. 2020 Jul 8;20(3):257–266. doi: 10.1007/s40268-020-00315-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 3 — Predicted versus observed concentrations of MgSO₄ over infusion time (VPC). The dotted lines represent the 5th, 50th, and 95th percentiles of the simulated data. The areas indicate the range of 90% predicted associated with the 5th, 50th, and 95th percentiles of the simulated data. The blue circles correspond to the observed values and the black circles to the predicted values. VPC visual predictive check