Table 3.
Estimated magnesium sulfate population parameters
| Fixed effect | Estimated | RSEa | % | p value | Bootstrap |
|---|---|---|---|---|---|
| V_pop | 13.3 | 0.112 | 8.43 | 13.3 | |
| CL_pop | 1.38 | 0.0239 | 17.4 | 1.4 | |
| Beta_CL_creatinine_mg_dL | − 0.0814 | 0.0279 | 34.2 | 0.00349 | |
| Beta_V_Weith_kg | + 0.0752 | 0.0187 | 28 | 0.00878 |
| Random effect | Estimated | Standard deviation | CV | p value | Bootstrap |
|---|---|---|---|---|---|
| Omega_V | 0.404 | 0.0777 | 19.3 | 0.403 | |
| Omega_CL | 0.015 | 0.00882 | 38.5 | 0.015 |
| Residual error | Estimated | Standard deviation | CV | ||
|---|---|---|---|---|---|
| a | 1.76 | 0.131 | 7.41 | ||
| b | 0.000552 | 0.0000363 | 6.57 | ||
| − 2 log-likelihood | 861.73 | ||||
| AIC | 877.73 | ||||
| BIC | 899.12 |
AIC Akaike information criteria, BIC Bayesian information criteria, CL clearance, CV coefficient of variation, RSE relative standard error, V distribution volume
aRSE = (standard error/estimated value) × 100