Table 4.

Covariate analysis with the best POPPK base model

Covariate	− 2LL	AIC	p value
Albumin on CL	915.873	935.948	0.33
Albumin on V	922.736	938.562	0.35
Total protein on CL	918.645	936.934	0.27
Total protein on V	917.374	937.487	0.22
Creatinine on CL	861.734	877.734	0.035
Creatinine on V	893.437	926.475	0.25
Age on CL	879.374	901.573	0.071
Age on V	894.571	913.846	0.13
Weight on CL	886.478	903.478	0.24
Weight on V	861.734	877.734	0.009
Comorbidities on CL	920.479	940.734	0.42
Comorbidities on V	912.873	937.493	0.39
Concomitant use of other drugs on CL	893.468	932.477	0.40
Concomitant use of other drugs on V	927.547	940.750	0.62

AIC Akaike information criteria, CL clearance, POPPK population pharmacokinetic, V distribution volume, − 2LL − 2 × log-likelihood