Table 1.
Cohorts of DOSIS
| Cohort | Participating centres | Population | Biobank collection | Aim |
|---|---|---|---|---|
| Erasmus HCM observational cohort | Erasmus MC | HCM patients and gene variant carriers | DNA | Identify predictive clinical markers for major cardiac events |
| BIO FOr CARe observational cohort | UMC Utrecht, UMC Groningen, Amsterdam UMC, Erasmus MC | All sarcomere gene variants | DNA, RNA (from blood), plasma and serum | Identify predictive biomarkers for major cardiac events |
| Telephone interviews | UMC Utrecht, UMC Groningen, Amsterdam UMC |
MYBPC3 founder gene variant carriers |
n.a. | Determine predictive value of environmental factors (especially exercise) for major cardiac events |
| ENERGY randomised placebo-controlled trial | Amsterdam UMC, Erasmus MC | Preclinical MYH7 gene variant carriers | Serum | Determine effects of trimetazidine on improving myocardial energy efficiency in the pre-clinical disease stage |
| Myectomy cohort | Erasmus MC, UMC Utrecht | HCM patients undergoing septal myectomy | DNA, cardiac tissue | Collect myocardial tissue for use in etiological studies |