Table 1.
Clinical characteristics
| Characteristics | All (n = 75) Mean ± SD (range) |
aSAH (N = 48) Mean ± SD (range) |
UIA (N = 27) Mean ± SD (range) |
ES IND (n = 35) Mean ± SD (range) |
FAM IND (n = 30) Mean ± SD (range) |
SPO IND (N = 45) Mean ± SD (range) |
|---|---|---|---|---|---|---|
| Age at SAH (years) | 46.9 ± 12.1 (9–71) | |||||
| IA (count) | 1.96 ± 1.40 (1–6) | 1.8 ± 1.3 (0–6) | 2.3 ± 1.6 (1–6) | 2.23 ± 1.57 (1–6) | 1.80 ± 1.27 (1–6) | 2.07 ± 1.48 (1–6) |
| Aneurysm diameter (mm) | 7.1 ± 6.6 (1.5–47.0) | 5.7 ± 2.6 (1.5–13.0) | 9.6 ± 910.2 (2.0–47.0) | 5.76 ± 3.22 (1.5–47.0) | 6.75 ± 5.95 (2.0–30.0) | 7.35 ± 7.07 (1.5–47.0) |
| Phases score | 4.8 (0–13) | 4.7 (0–12) | 5.0 (0–13) | 4.8 (0–13) | 4.5 (0–13) | 5.0 (0–12) |
| Hunt and hess grade | 2.3 (1–5) | |||||
| WFNS grade | 1.9 (1–5) | |||||
| Fisher score | 3.4 (1–4) | |||||
| Outcome at discharge (EGOS) | 4.9 (1–8) | |||||
| LAO (months) | 83 ± 298 (2–1343) | |||||
| Outcome LAO (MRS) | 1.3 (0–6) |
| Count (%) | Count (%) | Count (%) | Count (%) | Count (%) | Count (%) | |
| Sex | ||||||
| Female | 53 (70.7) | 35 (72.9) | 18 (66.7) | 26 (74.3) | 22 (73.3) | 31 (68.9) |
| Male | 22 (29.3) | 13 (17.3) | 9 (33.3) | 9 (25.7) | 8 (26.7) | 14 (31.1) |
| Aneurysm locationa | ||||||
| Anterior circulation | 56 (80.0) | 34 (77.3) | 22 (84.6) | 25 (75.8) | 22 (81.5) | 34 (79.1) |
| Posterior circulation | 11 (15.7) | 10 (22.7) | 1 (3.8) | 7 (21.2) | 5 (18.5) | 6 (14.0) |
| Both | 3 (4.3) | – | 3 (11.5) | 1 (3.0) | – | 3 (7.0) |
| Unknown | 5 | 2 | 3 | 2 | ||
| Family history | ||||||
| Yes | 30 (40) | 13 (27.1) | 17 (63.0) | 14 (60.0) | 30 (100.0) | 0 (0.0) |
| No | 45 (60) | 35 (72.9) | 10 (37.0) | 21 (40.0) | 0 (0.0) | 45 (100.0) |
| Vascular risk factors | ||||||
| Hypertension | 27 (36.5) | 13 (27.7) | 14 (51.9) | 13 (37.1) | 12 (41.4) | 15 (33.3) |
| Diabetes | 3 (4.1) | 1 (2.1) | 2 (7.4) | 1 (2.9) | 1 (3.4) | 2 (4.4.) |
| Hyperlipidemia | 6 (8.1) | 3 (6.4) | 3 (11.1) | 4 (11.4) | 3 (10.3) | 3 (6.7) |
| Prev. cardiovas. disease | 4 (5.5) | 2 (4.3) | 2 (7.4) | 2 (5.7) | 1 (3.4) | 3 (6.8) |
| Prev. neurol. disease | 12 (16.4) | 9 (19.6) | 3 (11.1) | 9 (25.7) | 1 (3.4) | 7 (15.9) |
| Ever smoker | 41 (56.2) | 28 (59.6) | 13 (50.0) | 20 (57.1) | 18 (62.1) | 23 (52.3) |
| Alcohol | 2 (2.7) | 2 (4.3) | 0 (0.0) | 1 (2.9) | 0 (0.0) | 2 (4.4) |
| Treatment | ||||||
| Endovascular | 34 (47.2) | 29 (63.0) | 5 (47.2) | 12 (36.4) | 8 (29.6) | 26 (57.8) |
| Surgical | 27 (37.5) | 13 (28.3) | 14 (53.8) | 15 (45.5) | 12 (44.4) | 15 (33.3) |
| Both | 11 (15.3) | 4 (8.7) | 7 (26.9) | 6 (18.2) | 7 (25.9) | 4 (8.9) |
| No | – | – | – | – | – | – |
| Unknown | 3 | 2 | 3 | |||
| DCI | ||||||
| Yes | 16 (38.1) | |||||
| No | 26 (61.9) | |||||
| Unknown | 6 | |||||
SD standard deviation, aSAH aneurysmal subarachnoid hemorrhage, UIA unruptured intracranial aneurysm, ES IND exome sequenced individuals, FAM IND individuals with positive family history, SPO IND substantially affected sporadic individuals, IA intracranial aneurysm, BMI body mass index, GCS Glasgow Coma Scale, WFNS World Federation of Neurosurgical Societies, EGOS Extended Glasgow Outcome Scale, LAO last available outcome, MRS Modified Rankin Scale, DCI delayed cerebral injury
aOnly the ruptured aneurysm was reported in the aSAH group