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. 2020 Aug 11;10:13552. doi: 10.1038/s41598-020-70666-y

Figure 4.

Figure 4

Transcriptional reprogramming of encoding fibrinogen binding protein (fib) gene in biofilms of MRSA treated with manuka honey. Gene expression data were normalized to the rpoB reference gene. Results are shown as n-fold changes in the target gene expression compared to the control (untreated biofilm). Significant differences in relative gene expression levels among examined MRSA samples were marked by different letters (a, b, d, e, cd, de) (Tukey’s test; p < 0.05). W: weak producer of biofilm; S: strong producer of biofilm; 4, 8, 12, 24: time of bacterial growth (h); MBIC: minimum biofilm inhibition concentration. Arithmetic mean and standard deviation, n = 3.