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. 2020 Aug 11;10:13573. doi: 10.1038/s41598-020-70171-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Comparison of the Markov chain model with existing experimental data. Our simulations were conducted for a fixed flow rates of 0.5 L/s which was the same as in the studies plotted. Probability of capture was plotted as a function of particle size. (B) Coronal projections of the 3D deposition and escape probabilities obtained from the Markov chain model, for comparison with gamma scintigraphy.