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. 2020 Aug 11;10:13553. doi: 10.1038/s41598-020-70454-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Empagliflozin modulates NOS activity and cardiac GCH1. (a,b) A representative western blot analysis of nNOS and eNOS activation. (c) NO levels. (d) O₂^.- levels. (e) Nitrotyrosine levels. (f) Confocal microscopy images following immunofluorescence analysis performed with cardiomyocytes expressing tubulin (green). Scale bar in image 4, also applicable to 1, 2 and 3, was 40 μm whereas in image 5 and 6, was 10 μm. (g) Model of Empagliflozin action in the myocardium. All quantifications derive from six independent experiments/group. The results are displayed as scatter plots and summarized with boxplots. **p < 0.01, ***p < 0.001.