Fig. 3. Central nesfatin-1 does not affect motivation to work for sucrose in a low-effort condition.

Effects of nesfatin-1 on the number of lever presses upon either i.c.v. (a) or VTA-specific administration (b) in ad libitum fed mice in the fixed ratio 1 schedule of reinforcement (N = 5). Operant behavioral sessions were performed at the beginning of the dark phase, began 30 min after drug administration and lasted 1 h. Data represent mean ± SEM.