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. 2020 Jul 31;18:2063–2074. doi: 10.1016/j.csbj.2020.07.019

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 3 — Diabetes-driven shifts in metabolic patterns in different brain regions of female mice. OPLS-DA score plots and VIP values based on the (A) hippocampus (R² = 0.848, Q² = 0.428), (B) cortex (R² = 0.895, Q² = 0.486), (C) cerebellum (R² = 0.848, Q² = 0.544), (D) striatum (R² = 0.869, Q² = 0.552), (E) hypothalamus (R² = 0.745, Q² = 0.210) and (F) midbrain (R² = 0.912, Q² = 0.626) metabolomes between normal control (CON) and type 1 diabetic (T1D) mice. Metabolite abbreviation: ADP, adenosine diphosphate; Ala, alanine; AMP, adenosine monophosphate; Asp, aspartate; Cho, choline; Cre/pCre, creatine/phosphocreatine; GABA, γ-Aminobutyric acid; Gln, glutamine; Glu, glutamate; Gly, glycine; IMP, inosine monophosphate; Ino, inosine; Lac, lactate; Myo, myo-inositol; NAA, N-acetylaspartate; NAD+, nicotinamide adeninedinucleotide; Suc, succinate; Tau, taurine.