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. 2020 Jul 31;18:2063–2074. doi: 10.1016/j.csbj.2020.07.019

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 6 — The effect of diabetes on metabolic pathway changes in different brain regions of mice. Metabolites showing a statistically significant diabetic effect (P < 0.05) were highlighted in metabolic pathways and colored according to their fold changes (T1D/CON). Metabolite abbreviation: ADP, adenosine diphosphate; Ala, alanine; AMP, adenosine monophosphate; Asp, aspartate; Cho, choline; Cre/pCre, creatine/phosphocreatine; GABA, γ-Aminobutyric acid; Gln, glutamine; Glu, glutamate; Gly, glycine; IMP, inosine monophosphate; Ino, inosine; Lac, lactate; Myo, myo-inositol; NAA, N-acetylaspartate; NAD+, nicotinamide adeninedinucleotide; Suc, succinate; Tau, taurine. Brain regions: Hip, hippocampus; Cor, cortex; Cer, cerebellum; Str, Striatum; Hyp, hypothalamus; Mid, midbrain. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)