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. 2020 Jul 29;12:6585–6595. doi: 10.2147/CMAR.S241383

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© 2020 Shen et al.

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MiR-98-5p mediates the sorafenib resistance of HEIH on sorafenib-resistant cells in HCC. HCCLM3/Sor and Huh7/Sor cells were transfected with anti-miR-NC, anti-miR-98-5p, si-HEIH + anti-miR-NC, si-HEIH + anti-miR-NC. (A) The expression of miR-98-5p was detected to confirm transfection efficiency. (B) CCK-8 assay analysis for the survival rates of resistant cells in combination with increasing concentrations of sorafenib was performed. (C) CCK-8 assay was used to measure the IC₅₀ values of resistant cells to sorafenib. (D) Flow cytometric analysis for resistant cell apoptosis was conducted. (E and F) The expressions of Bcl-2 and Bax in resistant cells were determined by Western blot assay. (G and H) The migration and invasion abilities of resistant cells were analyzed by transwell. *P<0.05.