FIGURE 2.

Schematic overview of the SGK1 role in different pathogenetic hypothesis of MDD. Under stress conditions, the increase of glucocorticoids induce a dysregulation of the GR/SGK1 axis, thus resulting in depressive behaviors, presumably dependent on anti-neurogenic activity exerting a negative regulation in the expression of neurotrophins, and/or the immune/inflammatory response as well. On the other hand, nutraceuticals-derived molecules with antioxidant, anti-inflammatory and neuro-protective properties, exhibit antidepressant effects due, at least in part, to the negative modulation of SGK1.