TABLE 1.

Table illustrating the SGK1 signaling partners in the MDD.

Interaction/Upstream/Downstream effectors	Papers	References
RAN	Maternal Stress Predicts Altered Biogenesis and the Profile of Mitochondrial Proteins in the Frontal Cortex and Hippocampus of Adult Offspring Rats.	Głombik et al., 2015
NF-KappaB	BDNF/NF-κB Signaling in the Neurobiology of Depression.	Caviedes et al., 2017
SP1	Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone.	Cheng et al., 2015
mTOR	The role of mTOR in depression and antidepressant responses.	Abelaira et al., 2014
IL-2, TGFβ and cytokines	Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut-brain pathways.	Martin-Subero et al., 2016
FOXO3a	IGF-1 defends against chronic-stress induced depression in rat models of chronic unpredictable mild stress through the PI3K/Akt/FoxO3a pathway. Th17 cells in depression.	Beurel and Lowell, 2018; Kuang et al., 2018

RAN, GTPase Ran; NF-KappaB, Nuclear Factor Kappa B; mTOR, mammalian Target of Rapamycin; IL-2, Interleukin 2; TGFβ, Transforming Growth Factor-beta; FOXO3a, Forkhead Box O3; BDNF, Brain-Derived Neurotrophic Factor; IFG-1, Insulin Like Growth Factor 1; PI3K, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase; Akt, Protein Kinase B.