Table 2.
HRs for Overall Survival Among NSCLC Patients
| Univariate Analysis | Multivariate Cox Regressiona | |||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| PASP (increase) | 1.039 (1.023–1.054) | <0.001 | 1.018 (1.003–1.034) | 0.020b |
| PASP ≥ 35mmHg (present) | 1.705 (1.296–2.243) | <0.001 | 1.386 (1.036–1.853) | 0.028c |
| Age (increase) | 1.029 (1.015–1.042) | <0.001 | 1.030(1.017–1.044) | < 0.001c |
| Sex (female) | 0.622 (0.478–0.810) | <0.001 | 0.179c | |
| Symptom (yes) | 2.852 (2.147–3.788) | <0.001 | 1.720(1.270–2.329) | < 0.001c |
| Smoke (yes) | 1.412 (1.148–1.735) | 0.001 | 0.540c | |
| GGO (yes) | 0.679 (0.467–0.987) | 0.042 | 0.692c | |
| CCI (>2) | 1.514 (1.169–1.960) | 0.002 | 0.598c | |
| Coagulopathy (yes) | 2.857 (2.204–3.703) | <0.001 | 1.363(1.030–1.804) | < 0.001c |
| Intrapulmonary metastasis (yes) | 2.892 (2.024–4.133) | <0.001 | 0.148c | |
| Lymph node metastasis (yes) | 2.848 (2.237–3.626) | <0.001 | 1.698(1.272–2.266) | < 0.001c |
| Distant metastasis (yes) | 3.696 (2.825–4.836) | <0.001 | 2.077(1.469–2.936) | < 0.001c |
| Histological type | <0.001 | 0.004c | ||
| Adenocarcinoma | 0.400 (0.253–0.633) | <0.001 | 0.447(0.279–0.718) | 0.001c |
| Squamous-cell carcinoma | 0.638 (0.400–1.019) | 0.06 | 0.476(0.292–0.776) | 0.003c |
| LVEF (increase) | 0.979 (0.966–0.993) | 0.003 | 0.123c | |
Notes: aThere were two Cox regression models. PASP (continuous, increase), PASP ≥ 35mmHg (dichotomous, referent: PASP < 35mmHg) were, respectively, distributed in models 1, 2. Age (continuous, increase), sex (dichotomous, referent: male), Symptom (dichotomous, referent: without symptom), Smoke (dichotomous, referent: non-smoking), GGO (dichotomous, referent: without-GGO), CCI (dichotomous, referent: CCI ≤ 2), coagulopathy (dichotomous, referent: without coagulation disorder), Intrapulmonary metastasis (dichotomous, referent: without Intrapulmonary metastasis), Lymph node metastasis (dichotomous, referent: without lymph node metastasis). Distant metastasis (dichotomous, referent: without distant metastasis), Clinical stage (dichotomous, referent: IA-IIB), LVEF (continuous, increase). bModel 1; cModel 2.