Figure 1.

Dual CAR strategies to improve efficacy of CAR T-cell MM therapy. (A) Mixture of two pools of single CAR T-cells in which each pool targets a different antigen. These can be co-infused or sequentially infused into a patient. (B) Two CARs targeting distinct antigens expressed on one T-cell through the use of co-transduction (B1) or a bicistronic vector (B2). Binding of either one of the CARs is sufficient to activate the T-cell. (C) Tandem CAR T-cells, which contain two distinct binding domains linked to one receptor. Binding of either one of the domains is sufficient to activate the T-cell. (D) Ligand-based CAR T-cells, containing a ligand as binding domain that can recognize more than one antigen. Binding of either one of the antigens is sufficient to activate the T-cell.