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. 2020 Aug 5;10:1371. doi: 10.3389/fonc.2020.01371

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Copyright © 2020 Shen, Song, Ren, Xu, Zhou, Liang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-27b-3p targets PPARG to regulate the EMT process and metastasis-related pathways. (A) Western blot analysis of PPARG, E-cadherin, Vimentin, Snail, and NF-κB after MDA-MB-231 cells were transfected by miR-27b-3p mimics or miR-27b-3p mimics together with PPARG agonist (GAPDH served as a loading control). (B) Relative expression analysis showed miR-27b-3p mimics activated EMT process and activated the expression of the metastasis-related transcription factors, while these effects were significantly repressed by PPARG agonists. For (B), results are shown as mean ± SD of 3 times of experiments in each group. *P < 0.05, **P < 0.01, ***P < 0.001; NC, negative control of transfection vectors.