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. 2020 Aug 5;11:1191. doi: 10.3389/fphar.2020.01191

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Copyright © 2020 Long, Chen, Wu, Li, Gao, Huang, Zhang, Jia and Xia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FG-4592 enhanced cardiac expression of HIF-1α, SOD2, and Bcl-2 in mice. (A, C, E) Western blots of HIF-1α, Bcl-2, and SOD2 in the left ventricular tissues from control and FG-4592-treated mice were measured by immunoblotting analysis. β-actin was used as the loading control. (B) Quantitation of the Western blots of HIF-1α. (D) Quantitation of the Western blots of Bcl-2. (F) Quantitation of the Western blots of SOD2. (G–I) mRNA levels of Bcl-2, BAX and NIX in the left ventricular tissues from control and FG-4592-treated mice by qRT-PCR. n=6-7 per group. *P < 0.05, and **P < 0.01.