Skip to main content
. 2020 Aug 5;10:1389. doi: 10.3389/fonc.2020.01389

Figure 2.

Figure 2

The role of MDMX in p53-MDM2/MDMX Loop. MDMX directly binds to p53 transactivation domains through its N-terminal p53-binding domain and inhibits p53-mediated transcription. MDMX also interacts with MDM2 via their RING domains and forms MDM2-MDMX heterodimer, increasing MDM2 protein stability and enhancing MDM2-mediated MDMX protein ubiquitination and degradation. Besides, the MDM2-MDMX complex shows better inhibitory effects on p53 than MDM2 alone, repressing p53-mediated transcription and promoting p53 ubiquitination and proteasomal degradation.