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. 2020 Aug 5;11:819. doi: 10.3389/fneur.2020.00819

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Copyright © 2020 Luckett, Lee, Park, Dierker, Daniel, Seitzman, Hacker, Ances, Leuthardt, Snyder and Shimony.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exemplar patient RS003 with glioblastoma multiforme in the left basal ganglia region. (A) Contrast-enhanced T1 and (B) fluid-attenuated inversion recovery demonstrating the tumor and surrounding edema. (C) Probability map of language network from 3DCNN with significant overlap of the tumor and (D) probability map of language from the T-fMRI also showing overlap over the tumor. Deep learning results show probabilities > 0.02. Task fMRI thresholds are varied in accordance with clinical practice.