Table 1.
Clinical Trials on the Basis of hPSCs by the End of 2019
| ICD-10 Main Chapter | Disease ICD-10 | Cellular Origin of Cell Product |
||||
|---|---|---|---|---|---|---|
| hESC | hiPSC | hpPSC | SCNT-hESC | Total | ||
| Neoplasms | malignant neoplasms (advanced solid tumors) | 0 | 2 | 0 | 0 | 5 |
| malignant neoplasm of bronchus and lung | 1 | 0 | 0 | 0 | ||
| myeloid leukemia | 0 | 1 | 0 | 0 | ||
| Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | beta-thalassemia | 0 | 2 | 0 | 0 | 2 |
| Endocrine, nutritional, and metabolic diseases | type 1 diabetes mellitus | 4 | 1 | 0 | 0 | 6 |
| primary ovarian failure | 1 | 0 | 0 | 0 | ||
| Diseases of the nervous system | Parkinson's disease | 0 | 3 | 2 | 0 | 6 |
| motor neuron disease | 1 | 0 | 0 | 0 | ||
| Diseases of the eye and adnexa | other retinal disorders | 4 | 0 | 0 | 0 | 25 |
| degeneration of macula and posterior pole: senile macular degeneration, dry age-related macular degeneration | 10 | 1 | 0 | 1 | ||
| hereditary retinal dystrophy: Retinitis pigmentosa | 2 | 0 | 0 | 0 | ||
| hereditary retinal dystrophy: Stargardt disease | 5 | 0 | 0 | 0 | ||
| other specified disorders of cornea (limbal stem cell deficiency) | 0 | 1 | 0 | 0 | ||
| degeneration of macula and posterior pole: wet age-related macular degeneration | 0 | 1 | 0 | 0 | ||
| Diseases of the circulatory system | ischemic heart diseases | 1 | 4 | 0 | 0 | 7 |
| cerebral infarction, unspecified | 0 | 2 | 0 | 0 | ||
| Diseases of the musculoskeletal system and connective tissue | derangement of meniscus due to old tear or injury | 1 | 0 | 0 | 0 | 1 |
| Injury, poisoning, and certain other consequences of external causes | injury of spinal cord, level unspecified | 2 | 0 | 0 | 0 | 3 |
| bone marrow transplant rejection | 0 | 1 | 0 | 0 | ||
| 32 | 19 | 2 | 1 | 54 | ||
Given are diseases targeted by the respective studies and the number of studies involving hESC-, hiPSC-, hpPSC-, and SCNT-hESC-derived cell products. Two Food and Drug Administration-approved hESC studies withdrawn before enrollment are not included.