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. 2020 Jul 16;15(2):424–438. doi: 10.1016/j.stemcr.2020.06.013

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Role of JMJD1A and JMJD1B in the Prospermatogonia to Spermatogonia Transition

In wild-type spermatogonia, JMJD1A and JMJD1B are highly expressed and the H3K9me2 mark is removed to extremely low levels in a JMJD1-dependent manner. This H3K9 hypomethylation status is critical for upregulation of SSC genes and the subsequent transition of prospermatogonia to spermatogonia after birth. In JMJD1A/JMJD1B-depleted spermatogonia, H3K9me2 is hypermethylated, resulting in low SSC gene expression and perturbed differentiation of prospermatogonia.