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. 2020 Jul 16;15(2):439–453. doi: 10.1016/j.stemcr.2020.06.015

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

UTX KO Neurons Have an Abnormal Gene Expression Profile that Is Related to the Development and Synaptic Function

(A) Gene ontology terms enriched in genes upregulated in UTX KO-derived neurons.

(B) Gene ontology terms enriched in genes downregulated in UTX KO-derived neurons.

(C) Volcano plot of downregulated genes (blue) and upregulated genes (red) in UTX KO-derived neurons. Genes associated with TGF-β signaling pathway (TGF-β1, TGF-β2, TGF-β3) and neural function (SLC6A1, SLC32A1, POU3F2, CAMK2A) are indicated.

(D) qPCR analysis verified that genes positively participated in synapse-related pathways were significantly downregulated in UTX KO neurons.

(E) qPCR analysis verified that genes positively participated in neural development were significantly downregulated in UTX KO neurons.

(F) qPCR analysis verified that genes positively participated in TGF-β signaling pathway were significantly upregulated in UTX KO neurons. Results are presented as mean ± SEM; n = at least 3 independent experiments. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. FC, fold change.