Figure 7.

UTX Resolves Bivalent Promoters for the Induction of Lineage-Specific Genes during Human Neural Differentiation

(A) Heatmap showing distribution of indicated groups of genomic regions on the chromatin states in NPCs modeled using ChromHMM (pro, promoters).

(B) Venn diagram of a combined comparison of 70 genes with downregulated expression and H3K27me3 gain with TFs.

(C) Left panel, boxplots showing changes of promoter H3K27me3 level of different conditions of 70 genes with downregulated expression and H3K27me3 gain; middle panel, boxplots showing changes of gene body H3K36me3 level of these genes; right panel, boxplots showing gene expression changes of these genes. (ChIP-seq and RNA-seq data of neural progenitor cell originated from H9 were downloaded from ENCODE [https://www.encodeproject.org/, biosample: ENCBS044KWE] and re-analyzed.)

(D) A hypothetical model of UTX as a bivalency-resolving demethylase necessary for neural differentiation of hESCs.