Table 6. Stratified analyses between IL-4 rs2243263 G>C polymorphism and CRC risk by sex, age, BMI, smoking status, and alcohol consumption.

Variable	IL-4 rs2243263 G>C (case/control)1			Adjusted OR2 (95% CI); P
	GG	GC	CC	GG	GC	CC	GC/CC	CC vs. (GC/GG)
Sex
Male	464/779	79/113	2/3	1.00	1.16 (0.83–1.61); P: 0.388	1.22 (0.18–8.29); P: 0.838	1.16 (0.84-1.61); P: 0.378	1.20 (0.18–8.11); P: 0.854
Female	151/269	17/36	1/1	1.00	0.86 (0.46–1.60); P: 0.636	1.37 (0.09–22.20); P: 0.825	0.88 (0.48–1.61); P: 0.674	1.39 (0.09–22.54); P: 0.816
Age
<63	215/392	34/59	1/3	1.00	1.06 (0.69–1.65); P: 0.780	0.55 (0.04–7.64); P: 0.656	1.05 (0.68–1.61); P: 0.836	0.55 (0.04–7.57); P: 0.652
≥63	400/656	62/90	2/1	1.00	1.12 (0.76–1.67); P: 0.567	1.98 (0.26–14.94); P: 0.507	1.14 (0.77–1.69); P: 0.503	1.95 (0.26–14.70); P: 0.517
Smoking status
Never	300/763	38/108	1/2	1.00	0.90 (0.60–1.34); P: 0.601	0.72 (0.07–7.31); P: 0.780	0.89 (0.60–1.33); P: 0.577	0.73 (0.07–7.41); P: 0.788
Ever	315/285	58/41	2/2	1.00	1.39 (0.89–2.18); P: 0.147	2.86 (0.23–35.48); P: 0.414	1.42 (0.91–2.21); P: 0.121	2.71 (0.22–33.47); P: 0.438
Alcohol consumption
Never	433/903	63/134	3/3	1.00	0.96 (0.69–1.33); P: 0.787	2.04 (0.39–10.55); P: 0.397	0.98 (0.71–1.36); P: 0.901	2.05 (0.40–10.61); P: 0.393
Ever	182/145	33/15	0/1	1.00	1.86 (0.93–3.73); P: 0.080	-	1.70 (0.86–3.35); P: 0.127	-
BMI (kg/m2)
<24	457/553	62/89	3/3	1.00	0.84 (0.59–1.22); P: 0.364	0.37 (0.04–3.96); P: 0.414	0.83 (0.58-1.19); P: 0.307	0.38 (0.04–4.04); P: 0.424
≥24	158/495	34/60	0/1	1.00	1.69 (1.05–1.2.71); P: 0.030	5.12 (0.42–62.14); P: 0.200	1.75 (1.10–2.78); P: 0.018	4.73 (0.39–57.51); P: 0.223

¹For IL-4 rs2243263 G>C, the genotyping was successful in 714 (99.03%) CRC cases and 1201 (99.42%) controls.

²Adjusted for multiple comparisons [age, sex, BMI, smoking status and alcohol consumption (besides stratified factors accordingly)] in a logistic regression model.

Bold values are statistically significant (P<0.05).