Table 7. Logistic regression analyses of association between HVEM rs2234167, IL-4 rs2070874, rs2243263 and IL-10 rs1800896 and rs1800872 polymorphisms and lymph node status in ESCC patients.
| Genotype | Positive (n=405) | Negative (n=316) | Crude OR (95% CI) | P | Adjusted OR1 (95% CI) | P | ||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | |||||
| HVEM rs2234167 G>A | ||||||||
| GG | 378 | 93.80 | 290 | 92.65 | 1.00 | 1.00 | ||
| GA | 24 | 5.96 | 23 | 7.35 | 0.80 (0.44–1.45) | 0.461 | 0.81 (0.44–1.49) | 0.500 |
| AA | 1 | 0.25 | 0 | 0 | - | - | - | - |
| GA + AA | 25 | 6.20 | 23 | 7.35 | 0.83 (0.46–1.50) | 0.544 | 0.84 (0.46–1.53) | 0.573 |
| GG+GA | 402 | 99.75 | 313 | 100.00 | 1.00 | 1.00 | ||
| AA | 1 | 0.25 | 0 | 0 | - | - | - | - |
| A allele | 26 | 3.23 | 23 | 3.67 | ||||
| IL-4 rs2070874 T>C | ||||||||
| TT | 275 | 68.24 | 211 | 67.41 | 1.00 | |||
| TC | 118 | 29.28 | 96 | 30.67 | 0.94 (0.68–1.30) | 0.723 | 0.91 (0.66–1.27) | 0.589 |
| CC | 10 | 2.48 | 6 | 1.92 | 1.28 (0.46–3.57) | 0.639 | 1.29 (0.45–3.70) | 0.637 |
| CC+TC | 128 | 31.76 | 102 | 32.59 | 0.96 (0.70–1.32) | 0.814 | 0.93 (0.68–1.29) | 0.681 |
| TT+TC | 393 | 97.52 | 307 | 98.08 | 1.00 | 1.00 | ||
| CC | 10 | 2.48 | 6 | 1.92 | 1.30 (0.47–3.62) | 0.613 | 1.33 (0.47–3.79) | 0.597 |
| C allele | 138 | 17.12 | 108 | 17.25 | ||||
| IL-4 rs2243263 G>C | ||||||||
| GG | 346 | 86.07 | 269 | 86.22 | 1.00 | 1.00 | ||
| GC | 54 | 13.42 | 42 | 13.46 | 1.00 (0.65–1.54) | 0.999 | 1.02 (0.65–1.59) | 0.932 |
| CC | 2 | 0.50 | 1 | 0.32 | 1.56 (0.14–17.24) | 0.719 | 2.18 (0.19–24.54) | 0.529 |
| CG+CC | 56 | 13.93 | 43 | 13.78 | 1.01 (0.66–1.55) | 0.955 | 1.04 (0.67–1.62) | 0.851 |
| GG+GC | 400 | 99.50 | 311 | 99.68 | 1.00 | 1.00 | ||
| CC | 2 | 0.50 | 1 | 0.32 | 1.56 (0.14–17.23) | 0.719 | 2.17 (0.19–24.43) | 0.531 |
| C allele | 58 | 7.21 | 44 | 7.05 | ||||
| IL-10 rs1800872 T>G | ||||||||
| TT | 195 | 48.51 | 154 | 49.20 | 1.00 | |||
| TG | 169 | 42.04 | 132 | 42.17 | 1.01 (0.74–1.38) | 0.944 | 1.01 (0.73–1.38) | 0.968 |
| GG | 38 | 9.45 | 27 | 8.63 | 1.11 (0.65–1.90) | 0.700 | 1.17 (0.68–2.03) | 0.576 |
| GG+TG | 207 | 51.49 | 159 | 50.80 | 1.03 (0.77–1.38) | 0.854 | 1.03 (0.76–1.40) | 0.828 |
| TT+TG | 364 | 90.55 | 286 | 88.54 | 1.00 | 1.00 | ||
| GG | 38 | 9.45 | 27 | 8.63 | 1.11 (0.66–1.86) | 0.703 | 1.17 (0.69–1.98) | 0.570 |
| G allele | 245 | 30.47 | 186 | 29.71 | ||||
| IL-10 rs1800896 T>C | ||||||||
| TT | 356 | 88.78 | 269 | 86.22 | 1.00 | |||
| TC | 43 | 10.72 | 41 | 13.14 | 0.79 (0.50–1.25) | 0.318 | 0.82 (0.51–1.31) | 0.404 |
| CC | 2 | 0.50 | 2 | 0.64 | 0.76 (0.11–5.40) | 0.780 | 0.88 (0.12–6.44) | 0.897 |
| CC+TC | 45 | 11.22 | 43 | 13.78 | 0.79 (0.51–1.24) | 0.303 | 0.82 (0.52–1.30) | 0.402 |
| TT+TC | 399 | 99.50 | 310 | 99.36 | 1.00 | 1.00 | ||
| CC | 2 | 0.50 | 2 | 0.64 | 0.78 (0.11–5.55) | 0.801 | 0.90 (0.12–6.61) | 0.918 |
| C allele | 47 | 5.86 | 45 | 7.21 | ||||
1
Adjusted for age, sex, smoking, alcohol use, and BMI status.