Table 8. Logistic regression analyses of association between HVEM rs2234167, IL-4 rs2070874, rs2243263 and IL-10 rs1800896 and rs1800872 polymorphisms and grades of ESCC.
| Genotype | G2+G3 (n=579) | G1 (n=142) | Crude OR (95% CI) | P | Adjusted OR1 (95% CI) | P | ||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | |||||
| HVEM rs2234167 G>A | ||||||||
| GG | 541 | 93.44 | 127 | 89.44 | 1.00 | 1.00 | ||
| GA | 33 | 5.70 | 14 | 9.86 | 0.55 (0.29–1.07) | 0.076 | 0.57 (0.30–1.11) | 0.099 |
| AA | 1 | 0.17 | 0 | 0 | - | - | - | - |
| GA + AA | 34 | 5.87 | 14 | 9.86 | 0.57 (0.30–1.09) | 0.091 | 0.59 (0.31–1.13) | 0.112 |
| GG+GA | 574 | 99.14 | 141 | 99.30 | 1.00 | 1.00 | ||
| AA | 1 | 0.17 | 0 | 0 | - | - | - | - |
| A allele | 35 | 3.02 | 14 | 4.93 | ||||
| IL-4 rs2070874 T>C | ||||||||
| TT | 391 | 67.53 | 95 | 66.90 | 1.00 | |||
| TC | 173 | 29.88 | 41 | 28.87 | 1.03 (0.68–1.54) | 0.905 | 1.06 (0.70–1.60) | 0.785 |
| CC | 11 | 1.90 | 5 | 3.52 | 0.54 (0.18–1.58) | 0.256 | 0.56 (0.19–1.66) | 0.296 |
| CC+TC | 184 | 31.78 | 46 | 32.39 | 0.97 (0.66–1.44) | 0.887 | 1.01 (0.68–1.50) | 0.981 |
| TT+TC | 564 | 97.41 | 136 | 95.77 | 1.00 | 1.00 | ||
| CC | 11 | 1.92 | 5 | 3.52 | 0.53 (0.18–1.55) | 0.247 | 0.55 (0.19–1.62) | 0.278 |
| C allele | 195 | 16.84 | 51 | 17.96 | ||||
| IL-4 rs2243263 G>C | ||||||||
| GG | 493 | 85.15 | 122 | 85.92 | 1.00 | 1.00 | ||
| GC | 78 | 13.47 | 18 | 12.68 | 1.07 (0.62–1.86) | 0.803 | 1.13 (0.65–1.96) | 0.674 |
| CC | 2 | 0.35 | 1 | 0.70 | 0.50 (0.05–5.50) | 0.567 | 0.62 (0.05–7.19) | 0.702 |
| CG+CC | 80 | 13.82 | 19 | 13.38 | 1.04 (0.61–1.78) | 0.882 | 1.10 (0.64–1.90) | 0.727 |
| GG+GC | 571 | 98.62 | 140 | 98.59 | 1.00 | 1.00 | ||
| CC | 2 | 0.35 | 1 | 0.70 | 0.49 (0.04–5.45) | 0.562 | 0.61 (0.05–7.03) | 0.690 |
| C allele | 82 | 7.08 | 20 | 7.04 | ||||
| IL-10 rs1800872 T>G | ||||||||
| TT | 269 | 46.46 | 80 | 56.34 | 1.00 | |||
| TG | 250 | 43.18 | 51 | 35.92 | 1.46 (0.99–2.16) | 0.059 | 1.49 (1.00–2.21) | 0.048 |
| GG | 55 | 9.50 | 10 | 7.04 | 1.64 (0.80–3.36) | 0.180 | 1.59 (0.77–3.27) | 0.211 |
| GG+TG | 305 | 52.68 | 61 | 42.96 | 1.49 (1.03–2.16) | 0.036 | 1.51 (1.04–2.19) | 0.032 |
| TT+TG | 519 | 89.64 | 131 | 92.25 | 1.00 | 1.00 | ||
| GG | 55 | 9.50 | 10 | 7.04 | 1.39 (0.69–2.80) | 0.359 | 1.34 (0.66–2.71) | 0.419 |
| G allele | 360 | 31.09 | 71 | 25.00 | ||||
| IL-10 rs1800896 T>C | ||||||||
| TT | 501 | 86.53 | 124 | 87.32 | 1.00 | |||
| TC | 68 | 11.74 | 16 | 11.27 | 1.05 (0.59–1.88) | 0.864 | 1.07 (0.60–1.93) | 0.809 |
| CC | 3 | 0.52 | 1 | 0.70 | 0.74 (0.08–7.20) | 0.797 | 0.88 (0.09–8.64) | 0.909 |
| CC+TC | 71 | 12.26 | 17 | 11.97 | 1.03 (0.59–1.82) | 0.909 | 1.06 (0.60–1.88) | 0.833 |
| TT+TC | 569 | 98.27 | 140 | 98.59 | 1.00 | 1.00 | ||
| CC | 3 | 0.52 | 1 | 0.70 | 0.74 (0.08–7.15) | 0.793 | 0.87 (0.09–8.55) | 0.903 |
| C allele | 74 | 6.39 | 18 | 6.34 | ||||
1
Adjusted for age, sex, smoking, alcohol use, and BMI status.
Bold values are statistically significant (P<0.05).