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. 2020 Jul 6;201(3):328–340. doi: 10.1111/cei.13473

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© 2020 The Authors. Clinical & Experimental Immunology published by John Wiley & Sons Ltd on behalf of British Society for Immunology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Fig. 2 — The effect of cladribine on microglia granularity and size. Microglia were treated with dimethylsulfoxide (DMSO) (0·2%), lipopolysaccharide (LPS) (10 ng/ml), DMSO and LPS, different concentrations of cladribine (CdA) (0·01 μM, 0·1 μM, 1 μM and 10 μM), and different concentrations of CdA together with LPS for 24 h. (a) A representative example of size [forward‐scatter (FSC)] and granularity [side‐scatter (SSC)] of microglia by flow cytometry. (b) The effect of CdA on the granularity (SSC) of naive and LPS‐stimulated microglia relative to DMSO control. (c) The effect of CdA on the size (FSC) of naive and LPS‐stimulated microglia relative to DMSO control. ***P ≤ 0·001, n = 3–4 in each group, one‐way analysis of variance (ANOVA) followed by multiple comparison tests, mean ± standard deviation (s.d.).