Table 3. Differences in Response to IV Hydrocortisone by Phenotype in a Propensity Score Matched Cohort of Patients With Vasoactive-Dependent Shock.
| Outcome | Phenotype 1 (n = 72) | Phenotype 2 (n = 71) | Phenotype 3 (n = 287) | Phenotype 4 (n = 230) | P valuea | ||||
|---|---|---|---|---|---|---|---|---|---|
| Treated (n = 39) | Untreated (n = 33) | Treated (n = 36) | Untreated (n = 35) | Treated (n = 146) | Untreated (n = 141) | Treated (n = 109) | Untreated (n = 121) | ||
| Vasoactive-free days, median (IQR) | 15 (0-25) | 17 (1-24) | 25 (23-26) | 24 (21-27) | 23 (1-26) | 18 (0-26) | 26 (23-27) | 26 (24-27) | <.001 |
| In-hospital mortality, No.(%) | 20 (51.3) | 14 (42.4) | 4 (11.1) | 4 (11.4) | 50 (34.2) | 65 (46.1) | 14 (12.8) | 9 (7) | .11 |
Abbreviations: IQR, interquartile range; IV, intravenous.
a
P value for interaction between IV hydrocortisone and phenotype membership using phenotype 2 as reference group (ie, 3 interaction terms) and analysis of deviance to test global significance.