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Synthesis and in vivo metabolism of water-soluble mucoadhesive nanogel. (A) Synthesis route of R9-PEG–P(LP-co-LC). (B) Schematic illustration for self-assembly of R9NG/HCPT, intravesical chemotherapy of R9NG/HCPT, superior mucoadhesiveness, enhanced penetrability, selective accumulation in tumor tissue, promoted internalization, and accelerated HCPT release from R9NG/HCPT.
