Table 3. . Cut-off values of ITGA4 methylation % of the four CpG sites for chronic lymphocytic leukemia diagnostic and prognostic evaluation.
| Variables | Cutoff % | Sensitivity % | Specificity % | AUC | 95% CI | p-value |
|---|---|---|---|---|---|---|
| CpG site-1 | 12.5 | 98.6 | 95.8 | 0.998 | 0.994–1.002 | <0.001‡ |
| CpG site-2 | 2.5 | 56.5 | 79.2 | 0.713 | 0.597–0.829 | 0.002‡ |
| CpG site-3 | 3.5 | 52.2 | 79.2 | 0.652 | 0.532–0.771 | 0.028† |
| CpG site-4 | 7.5 | 49.3 | 75.0 | 0.612 | 0.488–0.736 | 0.102 |
†
p < 0.05 is considered significant.
‡
p < 0.01 is considered highly significant.
AUC: Area under the curve.