Table 5. . Comparison between ITGA4 gene methylation % of the four CpG sites among patients with low and high levels of beta 2 microglobulin.

ITGA4 gene methylation %	CLL patients with low B2M <3.5 µg/ml (n = 9)	CLL patients with high B2M >3.5 µg/ml (n = 72)	p-value
CpG site-1 % (mean ± SE)	32.0 ± 2.7	26.3 ± 0.97	0.069
CpG site-2 % (mean ± SE)	4.6 ± 0.84	2.7 ± 0.12	0.014†
CpG site-3 % (mean ± SE)	5.5 ± 0.82	3.49 ± 0.17	0.012†
CpG site-4 % (mean ± SE)	9.37 ± 0.75	7.43 ± 0.29	0.005‡

^†p < 0.05 is considered significant;

^‡p < 0.01 is considered highly significant.

CLL: Chronic lymphocytic leukemia; SE: Standard error.