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. Author manuscript; available in PMC: 2020 Sep 6.
Published in final edited form as: Science. 2019 Sep 6;365(6457):eaaw9498. doi: 10.1126/science.aaw9498

Fig. 4. Averaging and phase separation create stability out of organizational variability.

Fig. 4.

(A) Because of the stability of the mRNA and protein products, highly variable and transient promoter-enhancer loops can nonetheless result in consistent numbers of mRNA molecules being transcribed, as well as consistent transcription profiles, within a cell or tissue. (B) Phase separation results in the segregation of molecules or DNA loci and can result in a stable nuclear body forming from a complex combination of variable associations.