Skip to main content
. 2020 Aug 12;12(1):e12095. doi: 10.1002/dad2.12095

FIGURE 3.

FIGURE 3

The dynamic change of Aβ markers in sporadic Alzheimer's disease. A, The change of Aβ in CSF. The time interval for CSF Aβ to transition from healthy controls to preclinical AD, from preclinical AD to MCI due to AD, and from MCI due to AD to dementia due to AD, was 32.6 (25th–75th: 25.7–44.4) years, 5.2 (25th–75th: 3.8–8.5) years, and 7.4 (25th‐=75th: 6.4–8.9) years, respectively. The time interval for CSF Aβ to transition from the level of healthy controls to cutoff value was 17.8 (25th–75th: 14.1–24.3) years. B, The change of Aβ deposition on amyloid imaging. The time interval to transition from healthy controls to MCI due to AD, and from MCI due to AD to dementia due to AD, was 22.6 (25th–75th: 21.1–24.5) years, and 9.1 (25th–75th: 8.5–9.7) years, respectively. The time interval for CSF Aβ to transition from the level of healthy controls to cutoff value was 5.0 (25th–75th: 4.7–5.4) years. Aβ, amyloid beta; AD, Alzheimer's disease; CSF, cerebrospinal fluid; MCI, mild cognitive impairment; SUVR, standard uptake value ratios on amyloid imaging.