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| Compound | IC50(μM) | ||||||
|---|---|---|---|---|---|---|---|
| CYP3A4 – midazolam | CYP3A4 – testosterone | CYP2C9 | CYP2D6 | CYP2C8 | CYP2B6 | CYP2C19 | |
| 6f | >20 | 6.6 | >20 | 0.92 | >20 | >20 | 8.8 |
| Ketoconazole† | 0.033 | 0.022 | – | – | – | – | – |
| Sulfaphenazole† | – | – | 0.16 | – | – | – | – |
| Quinidine† | – | – | – | 0.032 | – | – | – |
| Montelukast† | – | – | – | – | 0.14 | – | – |
| Tranylcypromine† | – | – | – | – | – | – | 7.5 |
| Ticlopidine† | – | – | – | – | – | 0.72 | – |
Control compounds.
IC50: 50% inhibition of growth.
