Table 2. . Activity against Mtb H37Rv at lower starting concentrations for bis-(imidazole/benzimidazole)-pyridine derivatives 2b, 5, 4f, 6c and 6f.
Compound | MIC aerobic condition (μM) | IC50 (μM) | IC90 (μM) |
---|---|---|---|
2b† | 101 | 93 | 100 |
5 | >50 | >50 | >50 |
4f† | 104 | 45 | 140 |
6c† | 87 | 34 | 110 |
6f† | 16 | 11 | 20 |
Rifampicin | 0.0063 | 0.0040 | 0.0077 |
Values indicate that compounds have a very good activity.
IC50: 50% inhibition of growth; IC90: 90% inhibition of growth; MIC: Minimum inhibitory concentration.