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. 2020 Jan 29;12(3):207–222. doi: 10.4155/fmc-2019-0063

Table 2. . Activity against Mtb H37Rv at lower starting concentrations for bis-(imidazole/benzimidazole)-pyridine derivatives 2b, 5, 4f, 6c and 6f.

Compound MIC aerobic condition (μM) IC50 (μM) IC90 (μM)
2b 101 93 100
5 >50 >50 >50
4f 104 45 140
6c 87 34 110
6f 16 11 20
Rifampicin 0.0063 0.0040 0.0077

Values indicate that compounds have a very good activity.

IC50: 50% inhibition of growth; IC90: 90% inhibition of growth; MIC: Minimum inhibitory concentration.