Table 4. . Low oxygen recovery assay for compounds 2b, 5, 4f, 6c and 6f.
| Compound | Low oxygen | Normal oxygen | ||||
|---|---|---|---|---|---|---|
| MIC (μM) | IC50 (μM) | IC90 (μM) | MIC (μM) | IC50 (μM) | IC90 (μM) | |
| 2b† | 200 | 26 | 91 | >200 | >200 | >200 |
| 5 | >50 | >50 | >50 | >50 | >50 | >50 |
| 4f† | 183 | 25 | 65 | 129 | 49 | 78 |
| 6c† | 200 | 16 | 130 | >200 | 17 | 60 |
| 6f† | 120 | 9.7 | 33 | 71 | 9.9 | 25 |
| Rifampicin | 0.13 | 0.0041 | 0.0065 | 0.096 | 0.0072 | 0.0025 |
| Metronidazole | 200 | 29 | 110 | >200 | >200 | >200 |
†
Values indicate that compounds have a very good activity.
IC50: 50% inhibition of growth; IC90: 90% inhibition of growth; MIC: Minimum inhibitory concentration.