Table 5. . MIC, IC50 and IC90 of compounds 2b, 5, 4f, 6c and 6f against Mtb resistant at different treatment and nontuberculous mycobacteria.
| Compound | INH-R1 | INH-R2 | RIF-R1 |
Mycobacterium avium |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MIC (μM) | IC50 (μM) | IC90 (μM) | MIC (μM) | IC50 (μM) | IC90 (μM) | MIC (μM) | IC50 (μM) | IC90 (μM) | MIC (μM) | |
| 2b† | 98 | 68 | 90 | 28 | 24 | 28 | 111 | 60 | 160 | – |
| 5 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | – |
| 4f† | 55 | 46 | 52 | 65 | 39 | 75 | 67 | 35 | 100 | >200 |
| 6c† | 120 | 42 | 170 | 110 | 42 | 150 | 87 | 24 | 110 | >200 |
| 6f† | 24 | 13 | 21 | 25 | 13 | 22 | 25 | 15 | 24 | 200 |
| C1 | 0.018 | 0.0084 | 0.022 | 0.065 | 0.0047 | 0.012 | 2 | 1.2 | 2.3 | >200 |
| C2 | >200 | >200 | >200 | >200 | >200 | >200 | 0.17 | 0.15 | 0.21 | – |
| C3 | 1.2 | 0.64 | 1.4 | 1.4 | 0.84 | 1.4 | 0.76 | 0.59 | 0.91 | – |
†
Values indicate that compounds have a very good activity.
C1: Rifampicin control; C2: Isoniazid control; C3: Levofloxacin control; FQ: Fluoroquinolone resistant strain; IC50: 50% inhibition of growth; IC90: 90% inhibition of growth; INH: Isoniazid resistant strain; MIC: Minimum inhibitory concentration; RIF: Rifampicin resistant strain.