Table 6. . MIC, IC50 and IC90 of compounds 2b, 5, 4f, 6c and 6f against Mtb resistant at different treatment and nontuberculous mycobacteria.
| Compound | RIF-R2 | FQ-R1 | Mycobacterium abscessus | ||||||
|---|---|---|---|---|---|---|---|---|---|
| MIC (μM) | IC50 (μM) | IC90 (μM) | MIC (μM) | IC50 (μM) | IC90 (μM) | MIC (μM) | IC50 (μM) | IC90 (μM) | |
| 2b | 68 | 38 | 61 | 102 | 66 | 92 | – | – | – |
| 5 | >50 | >50 | >50 | >50 | >50 | >50 | – | – | – |
| 4f† | >200 | 40 | 120 | 87 | 49 | 91 | 110 | 89 | 97 |
| 6c† | 100 | 44 | 120 | 200 | 40 | >200 | >200 | 120 | 200 |
| 6f† | 30 | 17 | 31 | 38 | 18 | 38 | 88 | 56 | 68 |
| C1 | >50 | >50 | >50 | 0.027 | 0.013 | 0.039 | 3.3 | 2.1 | 3.1 |
| C2 | 0.62 | 0.54 | 0.60 | 0.35 | 0.36 | 0.47 | – | – | – |
| C3 | 1.1 | 0.60 | 1.2 | 20 | 12 | 22 | – | – | – |
†
Values indicate that compounds have a very good activity.
C1: Rifampicin control; C2: Isoniazid control; C3: Levofloxacin control; FQ: Fluoroquinolone resistant strain; INH: Isoniazid resistant strain; MIC: Minimum inhibitory concentration; RIF: Rifampicin resistant strain.